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Latest in Hair Loss News
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New type of stem cell found in hair follicle - March 28, 2010
Hans Clevers and a team of Dutch and Swedish researchers conducted a study in mice and found that the stem cell that gives produces all the different cells of the skin actually lives in hair follicles.
The findings, which they say will translate for human use, mean it may be possible to harness these stem cells to help with wound repair or skin transplants for burns victims, they said in a study in the Science journal on Thursday.
"This is the mother of all the stem cells in the skin -- it makes all the other stem cells," Clevers, of the Royal Netherlands Academy of Arts and Sciences in Utrecht, told Reuters in a telephone interview.
"The same stem cells exist in humans, we can see them, and the promise is that these cells are probably going to be much better than anything we have had to date at making new skin."
The skin has three different populations of cells -- hair follicles, moisturizing sebaceous glands, and the tissue in between, known as the interfollicular epidermis. Stem cells are original cells, or drivers, from which all human cells develop.
Scientists had previously thought that stem cells in each of these three skin populations were capable of producing their own cell type, but until now, a "mother" stem cell which produces all three types had not been found.
Clevers' team found that a group of stem cells that live in hair follicles and which have high levels of a gene called Lgr6 are the original epidermal stem cells.
In tests on mice with wounds, they found that Lrg6 cells around the wound drove new skin growth and repaired the skin.
Scientists are already able to grow new skin in laboratories using tissue from existing skin cells from patients who have been badly burned, but the new skin is often brittle, dry and does not have hair -- making it look unusual.
Clevers said the advantage offered by the "mother" stem cell finding would be that they could grow skin from its original basis -- allowing it to be "real new skin" with moisture from sebaceous glands and the ability to grow hair.
He said researchers now need to learn how to isolate the Lrg6 cells from human skin. That could take 2 to 3 years.
"We are learning how to grow the mouse cells in culture. Once we know how to do this and can isolate the human variant, we should be able to grow human cells as well," he said.
"Since there is a lot of experience already with growing and transplanting skin for burn wound patients, it should be relatively easy to incorporate the new stem cells ... and conduct trials in patients."
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Hair Loss News Archive
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New type of stem cell found in hair follicle - March 28, 2010
Aderans purchases Intercytex assets - March 25, 2010
Aderans Research Treats One-Hundredth Subject in Clinical Study - April 1, 2009
Aderans Research launches second phase of Hair loss study - April 27, 2009
Intercytex anounces year end 2008 results, seeks partnership with hair transplantation company (Bosley) - March 20, 2009
Histogen will present preliminary clinical results of ReGenica efficacy for hair regrowth at stem cell summit - February 12, 2009
Intercytex publishes article on in vitro generation of proto-hair structures suitable for implantation. However, application of hair regeneration techniques in humans remains problematic. - February 11, 2009
Two-step hair follicle activation mechanisms is confirmed by scientists from Rockefeller University - February 10, 2009
Lexington International, LLC retains world renowned expert in laser phototherapy, Michael Hamblin, Ph.D, expanding its scientific advisory board - November 10, 2008
HairMax Lasercomb is approved by Korean FDA - November 8, 2008
Chinese scientists developed new method of mass production of reconstituted dermal papillae that can be used as basis for hair cloning - November 7, 2008
British and German scientists discovered new gene variant which is strongly associated with male pattern baldness - October 10, 2008
Scientists developed new platform for large-scale production of dermal papilla microtissues for hair follicle regeneration - July 31, 2008
Scientists show that hair follicle stem cells can promote repair of spinal cord injury and recovery of walking function - July 30, 2008
Scientists at USC identify new mechanism that controls activation of hair stem cells - Jan 14, 2008
2007 year-end clinical trial update from Intercytex - Dec 30, 2007
Using human hair follicle bulge cells Chinese researches constructed skin suitable for wound repair - Dec 28, 2007
Researches found potent precursor cells of neuronal lineage in dermal papilla of adult hairs - Sep 27, 2007
News study reports that wounded adult skin can regenerate new hair follicles. - May 16, 2007
HairMax LaserComb receives FDA clearance - February 14, 2007
Upcoming European Hair Research Society 2006 Annual Meeting - June 12, 2006
Intercytex Ltd. performs first human phase I Study on Follicular Cell Implantation in Manchester, UK - June 12, 2006
Aderans institute report their progress on hair cloning - January 18, 2006
Loss of stem cells causes hair graying - March 14, 2005
Interview with Dr. Lu Zhongfa - January 19, 2005
Dr Gho's clinic has financial problems - December 28, 2004
Tooth cells can induce formation of new hairs - December 28, 2004
Surprising report on human hair cloning comes from China - November 25, 2004
Do hair stem cells form blood vessels? - October 21, 2004
Human follicular stem cells: their presence in plucked hair and follicular cell culture - June 2, 2004
Adult hair follicle stem cells can be used to clone new hairs - March 15, 2004
Hairier mouse with longer penis overexpressed gene-called Noggin - March 2, 2004
Sawaya on the *real* story behind hair loss research - March 2, 2004
Hair follicle dermal cells can form bone and fat tissue - January 15, 2004
New hairs from bone marrow - December 2, 2003
LG 70-2 - potential new hair growth stimulators - June 18, 2003
Highlights of Upcoming SID Meeting - April 20, 2003
CD34 - New marker for hair stem cells. New tool for gene therapy and tissue engineering - April 3, 2003
Regeneration of a new hair follicle from the upper half of a human hair - November 8, 2002
Hair dermal papillae and dermal sheath cells can give rise to blood stem cells - October 23, 2002
Dermal papilla gene expression profile - September 16, 2002
Cell proliferation and death in male pattern baldness - August 29, 2002
Highlights of 63rd Annual Meeting of Society of Investigative Dermatology - Part II - June 17, 2002
Highlights of 63rd Annual Meeting of Society of Investigative Dermatology - Part I - May 31, 2002
Pigment stem cells in hair follice - May 6, 2002
Skin epithelila cells can originate from hematopoietic stem cells - April 9, 2002
Opinion of experts - March 15, 2002
Stem cells are present in mouse hair follicle bulb - February 27, 2002
Inhibition of beta-cat/Lef1 pathway in skin - January 30, 2002
Cloned hairlines - bisection of hair follicles - January 30, 2002
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