Hair Loss News - Intercytex publishes article on in vitro generation of proto-hair structures suitable for implantation. However, application of hair regeneration techniques in humans remains problematic.

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HairAid.com > News in Hair Loss and Hair Cloning

Hair Loss News : News Archive 2009

Intercytex publishes article on in vitro generation of proto-hair structures suitable for implantation. However, application of hair regeneration techniques in humans remains problematic.

Posted on: February 11, 2009

In the recent article published in journal "Future Medicine" scientists from Intercytex group describe technique that allows to generate proto-hair structures in vitro that retain the ability to fully develop into hair follicles after implantation.

In this study Intercytex scientists used follicular dermal and epidermal cells isolated from embryonic mouse skin. These cells were combined into multi-cellular aggregates that were further incubated in culture for 5–7 days and then implanted into skin of live recipient mice.

During culture, mixed cell aggregates developed into hair-like structures, termed "proto-hairs". Proto-hairs contained structures that resembled normal hair components, such as dermal papillae, hair matrix and rudimentary hair shafts. When implanted into mouse skin, they developed further into mature hair follicles capable of prolonged growth.

Authors suggests that if adopted in humans, in vitro proto-hair formation technique could provide a convenient and practical means by which follicular cells could be implanted for efficient hair regeneration to treat hair loss.

A the same time, Intercytex team acknowledges that: "Hair regeneration using implanted follicular cells has been demonstrated experimentally in a variety of animal models, but the methods are inefficient. A rapid and efficient method of hair regeneration is necessary for human hair restoration.". Also, they acknowledge that "the means to implant DP cells such that hair formation is efficiently and reliably induced continues to be a difficult challenge.". Collectively, Intercytex concludes that "while these systems are valuable for demonstrating the principle of hair induction by DP cells, they do not provide a means to efficiently hair in the human scalp."