Posted on: Dec 28, 2007
Chinese researches evaluated feasability of using human hair follicle bulge cells to repair full-thickness skin wound. They used technique based on combining cultured hair follicle stem cells with cultured dermal papilla cells. These two types of cells in proportion 1:2 respectively were seeded into PGA-collagen scaffolds. Then the keratinocyte sheets were seeded onto the surfaces of the scaffolds as bioengineered epidermis. These final engineered artificial skins were transplanted to repair the full-thickness wound in mouse model.
Such artificial skins were found to be effective in preparing full-thickness skin defects. However, no new hair follicles were formed in these experiments.
Reference: Wang HT, Chen B, Tang CW, Hu DH. (2007). Primary observation on construction of skin with human hair follicle bulge cells with tissue engineering technique. Zhonghua Shao Shang Za Zhi |
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